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pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with potent CYP3A4 inducers; these prescription drugs lower exposure to vandetanib by as many as 40%.pentobarbital will lessen the extent or impact of fosaprepitant by impacting hepatic/intestinal